Coachchem Laboratory Story | Episode twenty one:Let’s talk about soothing pathways


  1. Activation of TRPV1 receptors can cause itching, burning, redness, swelling, and tightness of the skin.

  2. SP and CGRP lead to skin redness and swelling, and SP can also cause itching and pain.

  3. Mast cell degranulation releases histamine, causing itching.

  4. TNF-α and NF-κB are important pro-inflammatory mediators closely associated with skin inflammation.

  5. Changes in emotions are also one of the culprits behind skin problems.