Coachchem Laboratory Story | Episode twenty two:Let’s talk about the soothing pathway — TRPV1 edition

  1. TRPV1 receptors are widely present in the skin and are associated with skin burning, redness, and inflammation.

  2. Activation of TRPV1 allows extracellular Ca2+ to flow into the cell, triggering the release of SP and CGRP from cells and neurons.

  3. Activation of TRPV1 is related to photoaging and retinoid-induced irritation.

  4. TRPV1 antagonists can soothe the skin, reduce sensitivity, and help mitigate retinoid-induced irritation.