Coachchem Laboratory Story | Episode twenty-four:Let’s talk about the soothing pathway — the SP and CGRP edition.

  1. SP and CGRP are classic neuropeptides that increase capillary permeability and cause vasodilation in the skin, leading to plasma leakage and edema, manifested as flushing and erythema.

  2. SP (Substance P) is a neurokinin that mediates degranulation of inflammatory cells and the inflammatory response.

  3. CGRP (Calcitonin Gene-Related Peptide) is a vasodilatory neuropeptide closely linked with SP.

  4. Inhibiting SP and CGRP can achieve a dual soothing effect, calming and reducing redness.