1. Tocopheryl retinoate does not cause phototoxicity, photoallergenicity, sensitization, acute skin irritation, or eye irritation, and it is negative for mutagenicity and teratogenicity.

2. The thermal and photostability of tocopheryl retinoate surpass that of HPR, making it the best among current vitamin A derivatives.

3. After 28 days of twice-daily use of 0.2% tocopheryl retinoate cream by 32 subjects, no skin reactions were observed.

4. The occlusive patch test with a high concentration (5% oil solution) of tocopheryl retinoate raw material was negative.

5. Tocopheryl retinoate is more stable, safer, and gentler.