China needs more than 2,000 kinds of raw materials and intermediates for chemical industry every year, with a demand of more than 2.5 million tons. After more than 30 years of development, the chemical raw materials and intermediates needed for pharmaceutical production in China can basically be matched, and only a small part of them need to be imported. Moreover, due to our rich resources and low prices of raw materials, a large number of intermediates have been exported. So, what development opportunities are China's pharmaceutical intermediates facing?
After nearly 50 years of development, a complete production system of beta-lactam antibiotics has been formed in China. In 2012, almost all of the beta-lactam antibiotics (except those in patent period) can be produced in China, and the cost is very low. Penicillin production ranks first in the world, and a large number of them are exported to the international market. Cephalosporin antibiotics can basically be self-sufficient, but also strive for some exports.
In 2012, all intermediates matched with beta-lactam antibiotics could be produced by our country. Except the mother nuclei of semi-synthetic antibiotics, 7-ACA and 7-ADCA, all side chain intermediates could be produced and exported in large quantities.
Taking phenylacetic acid, the main supporting intermediate of beta-lactam antibiotics, as an example, there are nearly 30 manufacturers of phenylacetic acid in China, with an annual production capacity of about 20,000 tons. However, most enterprises are small in scale, with the largest annual output of 2000 tons, and most others produce hundreds of tons annually. In 2003, the total domestic demand for phenylacetic acid was about 14,000 tons. The consumption structure was as follows: penicillin G accounted for 85%, other medicines accounted for 4%, spices accounted for 7%, pesticides and other fields accounted for 4%.
With the development of spices, medicine, pesticides and other industries in China, the demand for phenylacetic acid will further increase. It is expected that by 2005, the pharmaceutical industry will consume about 14,000 tons of phenylacetic acid, the pesticide industry will consume 500 tons and the spice industry will consume about 2,000 tons. In addition to consumption in other fields, the total domestic demand for phenylacetic acid is expected to reach 18,000 tons in 2005.